Rethinking Diabetes: A Weekly Review
Malattie Metaboliche e Diabetologia
The 89% Predictive Power: Rethinking GDM as a Multi-Faceted Interventional Target
Gestational diabetes affects 14% of pregnancies, but we're moving past the blood-sugar-only view. This week on Rethinking Diabetes, we analyze how oxidative stress links maternal obesity and GDM, and we reveal groundbreaking insights into high complication rates tied to preeclampsia and HELLP syndrome. Plus, we explore game-changing advances in diagnostics: from identifying 145 first-trimester biomarkers (like PAPP-A) and phthalate metabolites to using cord blood markers like IGF-1 to predict risks. Finally, we look at new management strategies, including the effectiveness of selenium supplementation and moderate-intensity exercise.
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Bibliografia
- Offspring Sequelae: Analysis of the immediate and late outcomes for children born to mothers with GDM and obesity (Kaza et al., #1).
- Gestational Diabetes Insipidus: Systematic review of case reports on the rare condition of gestational diabetes insipidus (González et al., #2).
- First-Trimester Biomarkers: Scoping review on potential GDM biomarkers identifiable in the first trimester of pregnancy (Swinburne et al., #3).
- Environmental Factors: Systematic review examining the impact of phthalate exposure on the development of GDM (Mitra et al., #4).
- Prediction Models: Study focusing on improving GDM prediction models using gestational age (Murphy et al., #5).
- Selenium Supplementation: Review and meta-analysis on the use of selenium supplementation for GDM management (Sun et al., #6).
- Neonatal Indicators: Research on the role of IGF-1 and leptin in cord blood as indicators related to GDM (Krause et al., #7).
- Influence of Snacking: Systematic review on the impact of snacking frequency and type on glycaemic control in women with GDM (Righton et al., #8).
- New Pharmacological Therapies: Systematic review on the development of GLP-1 agonists (like semaglutide) for GDM treatment (Alshehri, #9).
- Effects of Exercise: Meta-analysis on the effectiveness of physical exercise on blood glucose levels and pregnancy outcomes in women with GDM (Shu et al., #10).
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