Rethinking Diabetes: A Weekly Review
Malattie Metaboliche e Diabetologia
Advances in Diabetes Management and Metabolic Research
This week we discuss advances in diabetes management including once-weekly insulin icodec safety data, combination therapy with semaglutide, gender differences in hypoglycemia, and new approaches to cardiovascular risk prediction using proteomics.
Bibliography
1. Exercise or Fasting in Individuals With Type 2 Diabetes Receiving Once-Weekly Basal Insulin Icodec.
Authors: Pieber TR, Bajaj HS, Fluhr G, et al.
Journal: Diabetes, obesity & metabolism, 2026 Sep
PMID: 42387301
DOI: 10.1111/dom.71050
2. Anthropometric characteristics at birth and growth outcome in patients with X-linked hypophosphatemia treated with oral phosphate and active vitamin D.
Authors: Przygodda S, Brieger LC, Bohlen AV, et al.
Journal: Pediatric nephrology (Berlin, Germany), 2026 Sep
PMID: 41963716
DOI: 10.1007/s00467-026-07271-0
3. A validated, modifiable proteomic score from the EXSCEL trial predicts cardiovascular events in diabetes.
Authors: Corey KM, Nguyen M, Mi MY, et al.
Journal: JCI insight, 2026 Aug 24
PMID: 42390946
DOI: 10.1172/jci.insight.204463
4. Temporal changes in cortisol secretion and their association with long-term outcomes in benign adrenal incidentalomas: a retrospective cohort study.
Authors: Suntornlohanakul O, Reimondo G, Ghislieri M, et al.
Journal: The lancet. Diabetes & endocrinology, 2026 Sep
PMID: 42413529
DOI: 10.1016/S2213-8587(26)00098-7
5. Efficacy and Safety of Intensifying Once-Weekly Insulin Icodec Treatment With Once-Weekly Semaglutide in Adults With Type 2 Diabetes: A Single-Arm, Open-Label, Treat-to-Target, Phase 3b Trial (ONWARDS 8).
Authors: Strojek K, Liebl A, Mumbaikar NN, et al.
Journal: Diabetes, obesity & metabolism, 2026 Sep
PMID: 42387310
DOI: 10.1111/dom.71049
6. Gender differences in hypoglycaemia in type 1 and insulin-treated type 2 diabetes: the Hypo-METRICS study.
Authors: McCarthy A, Kent G, Thomas J, et al.
Journal: Diabetologia, 2026 Sep
PMID: 42322375
DOI: 10.1007/s00125-026-06775-6
7. Steatotic liver disease trajectory: A holistic EASL guidance on the multidisciplinary approach to screening and patient management.
Authors: Brouwer WP, Vonghia L, Thiele M, et al.
Journal: JHEP reports : innovation in hepatology, 2026 Sep
PMID: 42617506
DOI: 10.1016/j.jhepr.2026.101798
8. Islet ultrastructure: past achievements and future directions.
Authors: Müller A, Aurrecoechea Duran S, Santos PI, et al.
Journal: Diabetologia, 2026 Sep
PMID: 42426419
DOI: 10.1007/s00125-026-06782-7
Authors: Pieber TR, Bajaj HS, Fluhr G, et al.
Journal: Diabetes, obesity & metabolism, 2026 Sep
PMID: 42387301
DOI: 10.1111/dom.71050
2. Anthropometric characteristics at birth and growth outcome in patients with X-linked hypophosphatemia treated with oral phosphate and active vitamin D.
Authors: Przygodda S, Brieger LC, Bohlen AV, et al.
Journal: Pediatric nephrology (Berlin, Germany), 2026 Sep
PMID: 41963716
DOI: 10.1007/s00467-026-07271-0
3. A validated, modifiable proteomic score from the EXSCEL trial predicts cardiovascular events in diabetes.
Authors: Corey KM, Nguyen M, Mi MY, et al.
Journal: JCI insight, 2026 Aug 24
PMID: 42390946
DOI: 10.1172/jci.insight.204463
4. Temporal changes in cortisol secretion and their association with long-term outcomes in benign adrenal incidentalomas: a retrospective cohort study.
Authors: Suntornlohanakul O, Reimondo G, Ghislieri M, et al.
Journal: The lancet. Diabetes & endocrinology, 2026 Sep
PMID: 42413529
DOI: 10.1016/S2213-8587(26)00098-7
5. Efficacy and Safety of Intensifying Once-Weekly Insulin Icodec Treatment With Once-Weekly Semaglutide in Adults With Type 2 Diabetes: A Single-Arm, Open-Label, Treat-to-Target, Phase 3b Trial (ONWARDS 8).
Authors: Strojek K, Liebl A, Mumbaikar NN, et al.
Journal: Diabetes, obesity & metabolism, 2026 Sep
PMID: 42387310
DOI: 10.1111/dom.71049
6. Gender differences in hypoglycaemia in type 1 and insulin-treated type 2 diabetes: the Hypo-METRICS study.
Authors: McCarthy A, Kent G, Thomas J, et al.
Journal: Diabetologia, 2026 Sep
PMID: 42322375
DOI: 10.1007/s00125-026-06775-6
7. Steatotic liver disease trajectory: A holistic EASL guidance on the multidisciplinary approach to screening and patient management.
Authors: Brouwer WP, Vonghia L, Thiele M, et al.
Journal: JHEP reports : innovation in hepatology, 2026 Sep
PMID: 42617506
DOI: 10.1016/j.jhepr.2026.101798
8. Islet ultrastructure: past achievements and future directions.
Authors: Müller A, Aurrecoechea Duran S, Santos PI, et al.
Journal: Diabetologia, 2026 Sep
PMID: 42426419
DOI: 10.1007/s00125-026-06782-7
