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Diabetes Management Breakthroughs: From Liver Fibrosis to Neuropathy

Rethinking Diabetes: A Weekly Review

Malattie Metaboliche e Diabetologia

Diabetes Management Breakthroughs: From Liver Fibrosis to Neuropathy

This week's episode explores groundbreaking research in diabetes management, from cardiovascular benefits of SGLT2 inhibitors in patients with liver fibrosis to new approaches for diabetic neuropathy and pediatric obesity interventions.

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Bibliografia

1. Effects of Dapagliflozin on Cardiovascular Outcomes in Patients With Type 2 Diabetes at Risk of Liver Fibrosis.
Authors: Oscarsson J, Huhn M, Jiang Y, et al.
Journal: Diabetes, obesity & metabolism, 2026 Jul
PMID: 42046405
DOI: 10.1111/dom.70820


2. Pediatric obesity-Long-term consequences and effect of weight loss.
Authors: Marcus C, Danielsson P, Hagman E
Journal: Journal of internal medicine, 2022 Dec
PMID: 35883220
DOI: 10.1111/joim.13547


3. Sodium-glucose cotransporter-2 inhibitors (SGLT2) in frail or older people with type 2 diabetes and heart failure: a systematic review and meta-analysis.
Authors: Aldafas R, Crabtree T, Alkharaiji M, et al.
Journal: Age and ageing, 2024 Jan 2
PMID: 38287703
DOI: 10.1093/ageing/afad254


4. Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments.
Authors: Elafros MA, Andersen H, Bennett DL, et al.
Journal: The Lancet. Neurology, 2022 Oct
PMID: 36115364
DOI: 10.1016/S1474-4422(22)00188-0


5. Bariatric Surgery versus Intensive Medical Therapy for Diabetes - 5-Year Outcomes.
Authors: Schauer PR, Bhatt DL, Kirwan JP, et al.
Journal: The New England journal of medicine, 2017 Feb 16
PMID: 28199805
DOI: 10.1056/NEJMoa1600869


6. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
Authors: Didangelos T, Karlafti E, Kotzakioulafi E, et al.
Journal: Nutrients, 2021 Jan 27
PMID: 33513879
DOI: 10.3390/nu13020395


7. Glial cell alterations in diabetes-induced neurodegeneration.
Authors: Llorián-Salvador M, Cabeza-Fernández S, Gomez-Sanchez JA, et al.
Journal: Cellular and molecular life sciences : CMLS, 2024 Jan 18
PMID: 38236305
DOI: 10.1007/s00018-023-05024-y


8. Effects of Dietary Approaches and Exercise Interventions on Gestational Diabetes Mellitus: A Systematic Review and Bayesian Network Meta-analysis.
Authors: Zhang L, Wang F, Tashiro S, et al.
Journal: Advances in nutrition (Bethesda, Md.), 2024 Dec
PMID: 39481539
DOI: 10.1016/j.advnut.2024.100330


9. Vitamin D as a Lifespan Neuroimmune Signal in Psychiatry: From Developmental Risk to Precision Nutrition.
Authors: Ducki C, Jach M, Pruc M, et al.
Journal: Nutrients, 2026 Jun 10
PMID: 42356264
DOI: 10.3390/nu18121877


10. Safety and efficacy of intermittent fasting with or without exercise in people living with overweight or obesity and type 2 diabetes-The INTERFAST-3 study design.
Authors: Sourij C, Müller A, Al-Baghdadi A, et al.
Journal: Diabetic medicine : a journal of the British Diabetic Association, 2026 Jul
PMID: 41986966
DOI: 10.1111/dme.70328

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