Inside Nephrology: A Weekly Review
Nefrologia
Revolutionizing Kidney Care: The Mitochondria Connection
In this episode we explore how mitochondrial dysfunction drives kidney disease, the expanding role of SGLT2 inhibitors, and the systemic nature of CKD-related risks. We highlight breakthroughs in biomarkers, nanotechnology-based therapies, and new pediatric guidelines—revealing a shift toward precision and preventive nephrology.
Bibliography
- Marx-Schütt M, Schneider MP, Eckardt K-U, Titze SI. Cardiovascular disease in chronic kidney disease: Pathophysiological insights and therapeutic options. Eur Heart J. 2025;46(4):250–62.
- Akunjee M, Mahadevan K, Steuber T, Kirsztajn GM. Beyond glycemic control: The expanding role of SGLT2 inhibitors in kidney and cardiovascular protection. Am J Physiol Endocrinol Metab. 2025;328(2):E285–94.
- Clerici C, Boletta A. Metabolic reprogramming in renal ciliopathies: Insights into mitochondrial dysfunction and potential therapeutic targets. EMBO Mol Med. 2025;17(3):e18512.
- Teixeira JP, Greenberg A, Mehrotra R. Innovations in kidney replacement therapies: KDIGO 2024 update. Am J Kidney Dis. 2025;85(1):34–45.
- Marlais M, Mekahli D. Tuberous sclerosis complex and kidney disease in children: New guidelines for early intervention. Pediatr Nephrol. 2025;40(2):123–30.
- Cho M, Park Y, Kim S. Endothelial dysfunction and cardiovascular risk in CKD: Mechanistic insights. Am J Physiol Heart Circ Physiol. 2025;328(1):H1–9.
- Pavlović D, Ferluga D, Horvat M. Mitochondrial dysfunction and inflammation in chronic kidney disease: A bidirectional relationship. Cells. 2025;14(3):487.
- Chen W, Zhao L, Sun M. Mitochondrial-targeted therapies in diabetic nephropathy: A review of current evidence. Ren Fail. 2025;47(1):e2152437.
- Awdishu L, Pai AB, Nolin TD. KDIGO 2024 guidelines: Pharmacotherapeutic implications for chronic kidney disease. Am J Health Syst Pharm. 2025;82(2):e34–43.
- Cao Y, Zhang J, Liu R. Novel biomarkers in diabetic kidney disease: Integrating traditional and emerging indicators. Front Endocrinol (Lausanne). 2025;16:1213.
