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Inside Nephrology: A Weekly Review
Nefrologia
Medical Insights: Stroke Recovery, ICU Sedation, and ALS Breakthroughs
This week we discuss groundbreaking studies on stroke rehabilitation, ICU sedation strategies, a potential ALS treatment breakthrough, oral vs IV antibiotics for bone infections, and a promising new atopic dermatitis therapy.
Bibliography
1. A Very Early Rehabilitation Trial after stroke (AVERT): a Phase III, multicentre, randomised controlled trial.
Authors: Langhorne P, Wu O, Rodgers H, et al.
Journal: Health technology assessment (Winchester, England)
PMID: 28967376
DOI: 10.3310/hta21540
2. Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial.
Authors: Walsh TS, Parker RA, Aitken LM, et al.
Journal: JAMA
PMID: 40388916
DOI: 10.1001/jama.2025.7200
3. Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Authors: Oki R, Izumi Y, Fujita K, et al.
Journal: JAMA neurology
PMID: 35532908
DOI: 10.1001/jamaneurol.2022.0901
4. Oral versus Intravenous Antibiotics for Bone and Joint Infection.
Authors: Li HK, Rombach I, Zambellas R, et al.
Journal: The New England journal of medicine
PMID: 30699315
DOI: 10.1056/NEJMoa1710926
5. Phase 2b randomized clinical trial of amlitelimab, an anti-OX40 ligand antibody, in patients with moderate-to-severe atopic dermatitis.
Authors: Weidinger S, Blauvelt A, Papp KA, et al.
Journal: The Journal of allergy and clinical immunology
PMID: 39522654
DOI: 10.1016/j.jaci.2024.10.031
Authors: Langhorne P, Wu O, Rodgers H, et al.
Journal: Health technology assessment (Winchester, England)
PMID: 28967376
DOI: 10.3310/hta21540
2. Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial.
Authors: Walsh TS, Parker RA, Aitken LM, et al.
Journal: JAMA
PMID: 40388916
DOI: 10.1001/jama.2025.7200
3. Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Authors: Oki R, Izumi Y, Fujita K, et al.
Journal: JAMA neurology
PMID: 35532908
DOI: 10.1001/jamaneurol.2022.0901
4. Oral versus Intravenous Antibiotics for Bone and Joint Infection.
Authors: Li HK, Rombach I, Zambellas R, et al.
Journal: The New England journal of medicine
PMID: 30699315
DOI: 10.1056/NEJMoa1710926
5. Phase 2b randomized clinical trial of amlitelimab, an anti-OX40 ligand antibody, in patients with moderate-to-severe atopic dermatitis.
Authors: Weidinger S, Blauvelt A, Papp KA, et al.
Journal: The Journal of allergy and clinical immunology
PMID: 39522654
DOI: 10.1016/j.jaci.2024.10.031
