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Advancements in Gynecology: A Weekly Review

Ginecologia e Ostetricia

Revolutionizing Disease Detection with AI and Biomarkers

This episode covers major advances in gynecology and women’s health, from AI-driven early detection of pancreatic cancer to new insights on endometriosis, maternal health, and metabolic influences on disease. We highlight promising results from oral GnRH antagonists, exosome markers for preeclampsia, and the role of creatine in cognitive and bone health. A quick but impactful roundup of recent findings shaping the future of personalized care.

Bibliography

References:


– Murray K, Oldfield L, Stefanova I, Gentiluomo M, Aretini P, O'Sullivan R, Greenhalf W, Paiella S, Aoki MN, Pastore A, Birch-Ford J, Rao BH, Uysal-Onganer P, Walsh CM, Hanna GB, Narang J, Sharma P, Campa D, Rizzato C, Turtoi A, Sever EA, Felici A, Sucularli C, Peduzzi G, Öz E, Sezerman OU, Van der Meer R, Thompson N, Costello E. Biomarkers, omics and artificial intelligence for early detection of pancreatic cancer. Semin Cancer Biol. 2025 Jun;111:76-88. doi:10.1016/j.semcancer.2025.02.009. Epub 2025 Feb 20. PMID: 39986585.

– Di Spiezio Sardo A, Becker CM, Renner SP, Suvitie PA, Tarriel JE, Vannuccini S, Garcia Velasco JA, Verguts J, Mercorio A. Management of women with endometriosis in the 21st century. Curr Opin Obstet Gynecol. 2025 Jun 1;37(3):149-157. doi:10.1097/GCO.0000000000001027. Epub 2025 Apr 10. PMID: 40237624; PMCID: PMC12039902.

– Yamagata K, Mizuno Y, Mizuno Y, Tamaru S, Kajihara T. Androgens modulate endometrial function. Med Mol Morphol. 2025 Jun;58(2):93-99. doi:10.1007/s00795-025-00430-6. Epub 2025 Mar 10. PMID: 40063300; PMCID: PMC12103470.

– Russ JB, Agarwal S, Venkatesan C, Scelsa B, Vollmer B, Tarui T, Pardo AC, Lemmon ME, Mulkey SB, Hart AR, Nagaraj UD, Kuller JA, Whitehead MT, Cohen JL, Gebb JS, Glenn OA, Norton ME, Gano D. Fetal malformations of cortical development: review and clinical guidance. Brain. 2025 Jun 3;148(6):1888-1903. doi:10.1093/brain/awaf094. PMID: 40048696; PMCID: PMC12129737.

– David M, Maharaj N. The immune-modulatory dynamics of exosomes in preeclampsia. Arch Gynecol Obstet. 2025 Jun;311(6):1477-1487. doi:10.1007/s00404-025-08013-7. Epub 2025 Apr 3. PMID: 40178562; PMCID: PMC12055642.

– Smith-Ryan AE, DelBiondo GM, Brown AF, Kleiner SM, Tran NT, Ellery SJ. Creatine in women's health: bridging the gap from menstruation through pregnancy to menopause. J Int Soc Sports Nutr. 2025 Dec;22(1):2502094. doi:10.1080/15502783.2025.2502094. Epub 2025 May 15. PMID: 40371844; PMCID: PMC12086928.

– Valabrega G, Powell MA, Hietanen S, Miller EM, Novak Z, Holloway R, Denschlag D, Myers T, Thijs AM, Pennington KP, Gilbert L, Fleming E, Zub O, Landrum LM, Ataseven B, Gogoi R, Podzielinski I, Cloven N, Monk BJ, Sharma S, Herzog TJ, Stuckey A, Pothuri B, Secord AA, Chase D, Vincent V, Meyers O, Garside J, Mirza MR, Black D. Patient-reported outcomes in the subpopulation of patients with mismatch repair-deficient/microsatellite instability-high primary advanced or recurrent endometrial cancer treated with dostarlimab plus chemotherapy compared with chemotherapy alone in the ENGOT-EN6-NSGO/GOG3031/RUBY trial. Int J Gynecol Cancer. 2025 Jun;35(6):101852. doi:10.1136/ijgc-2024-005484. Epub 2025 Apr 19. PMID: 39322611.

– Sarkar M, Kushner T. Metabolic dysfunction-associated steatotic liver disease and pregnancy. J Clin Invest. 2025 May 15;135(10):e186426. doi:10.1172/JCI186426. PMID: 40371643; PMCID: PMC12077888.

– Yang X, Xue X, Zhu Y, Zhang Z. Correlation between lipid metabolism and endometriosis: a meta-analysis. Gynecol Endocrinol. 2025 Dec;41(1):2500459. doi:10.1080/09513590.2025.2500459. Epub 2025 May 9. PMID: 40343766.

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