Advancements in Gynecology: A Weekly Review
Ginecologia e Ostetricia
Freezing Time: The New Era of Fertility Preservation
This episode explores the latest data on oocyte cryopreservation, including live birth rates over 75% when performed before age 35. We examine shifting trends in timing, cultural perspectives, and accessibility — and why this technology is becoming less about career planning and more about reproductive autonomy. Featuring insights from major studies and meta-analyses, it’s a concise, evidence-based look at how fertility preservation is reshaping reproductive medicine.
Bibliography
- Cobo A, Cascante SD, García-Velasco J, Grifo JA. Is planned oocyte cryopreservation delivering? Reprod Biomed Online. 2025;50(4):104794. doi:10.1016/j.rbmo.2025.104794. PMID: 40287213.
- Klipstein S, Kelly L, Lalwani S. No guarantees: planned oocyte cryopreservation, not quite an insurance policy. Arch Gynecol Obstet. 2024;310(4):1889–94. doi:10.1007/s00404-024-07654-4. PMID: 39096366. PMCID: PMC11393050.
- Dufour S, et al. Oocyte cryopreservation outcomes in women with hematological malignancies – a systematic review and meta-analysis. J Obstet Gynaecol Can. 2025;47(6):102824. doi:10.1016/j.jogc.2025.102824. PMID: 40157648.
- Ngan OM, et al. Planned oocyte cryopreservation in Hong Kong: a potential prototype for mainland China. Sex Reprod Health Matters. 2025;33(1):2485547. doi:10.1080/26410397.2025.2485547. PMID: 40413668. PMCID: PMC12107638.
- Zhang H, et al. Mature oocyte found during ovarian tissue cryopreservation in an early adolescent female. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024;53(4):527–30. doi:10.3724/zdxbyxb-2023-0561. PMID: 39183059. PMCID: PMC11375484.
- Tandoğan Ö, et al. Acceptance rates and reasons for social oocyte cryopreservation: systematic review and meta-analysis. J Assist Reprod Genet. 2025;42(5):1525–38. doi:10.1007/s10815-025-03425-5. PMID: 40024978. PMCID: PMC12167205.
- Shavit T, et al. Trends in patient age at planned oocyte cryopreservation. J Assist Reprod Genet. 2024;41(11):2973–7. doi:10.1007/s10815-024-03237-z. PMID: 39235517. PMCID: PMC11621261.
- Ter Welle-Butalid ME, et al. Fertility preservation with oocyte/embryo cryopreservation: a population-based study in the Netherlands. Hum Reprod. 2024;39(12):2693–701. doi:10.1093/humrep/deae243. PMID: 39479806. PMCID: PMC11630040.
