Advancements in Gastroenterology: A Weekly Review
Gastroenterologia
Liver-Cardiovascular Crosstalk and Emerging GI Therapies
This week we explore the liver-cardiovascular connection, CAR-T therapy complications, plant-based IBS treatments, and emerging immunometabolic targets. Plus, updates on GLP-1 adverse effects and HCC prognostic factors.
Bibliography
1. Cardiovascular Complications of Chronic Liver Disease.
Authors: Park S, Gupta DK, Izzy M, et al.
Journal: Circulation, 2026 Oct 13
PMID: 42862908
DOI: 10.1161/CIRCULATIONAHA.126.079443
2. Review Article: Immune Effector Cell-Mediated Enterocolitis Following CAR-T Cell Therapy-Clinical Features, Pathophysiology and Management.
Authors: Damianos JA, Lin Y, Chen ZE, et al.
Journal: Alimentary pharmacology & therapeutics, 2026 Oct
PMID: 42596026
DOI: 10.1111/apt.70920
3. Systematic Review and Meta-Analysis: Plant-Based Therapy for Irritable Bowel Syndrome.
Authors: Meyer A, Auer J, Cascant-Ortolano L, et al.
Journal: Phytotherapy research : PTR, 2026 Oct
PMID: 42572206
DOI: 10.1002/ptr.70421
4. Targeting the CD31 immunometabolic axis: Precision strategies for modulating T cell activation, migration, and autophagy.
Authors: Han X, Yang F, Huang C, et al.
Journal: Pathology, research and practice, 2026 Oct
PMID: 42492206
DOI: 10.1016/j.prp.2026.156629
5. Gastrointestinal adverse effects of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists: A narrative expert review of approved therapies, oral formulations, and pipeline agents.
Authors: Singhani V, Ehsan M, Valencia S, et al.
Journal: Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2026 Oct
PMID: 42808923
DOI: 10.1002/ncp.70180
6. Impact of body composition on clinical outcomes in patients with hepatocellular carcinoma: A systematic review and meta-analysis.
Authors: Pinto E, Barberio B, Gambato M, et al.
Journal: Hepatology communications, 2026 Nov 1
PMID: 42878582
DOI: 10.1097/HC9.0000000000001063
7. Impact of immune checkpoint inhibitors as neoadjuvant/perioperative therapy for locally advanced resectable gastric/gastroesophageal junction adenocarcinoma: a systematic review and meta-analysis.
Authors: Chen Z, Liu X, Sun H, et al.
Journal: Frontiers in immunology, 2026
PMID: 42857192
DOI: 10.3389/fimmu.2026.1909466
8. Effect of a Phenotype-Tailored Lifestyle Intervention on Caloric Intake and Macronutrient Composition in Adults with Obesity: A Secondary Analysis of the PHENO-Diet Trial.
Authors: Espinosa MA, Sefried L, Villamarin J, et al.
Journal: Nutrients, 2026 Sep 25
PMID: 42884609
DOI: 10.3390/nu18193159
9. Safety Profiles of Immune Checkpoint Inhibitor Strategies in Gastrointestinal Cancers and Their Association With Clinical Outcomes: A Systematic Review and Meta-Analysis.
Authors: Lei J, Yu Y, Liu Q, et al.
Journal: Cancer medicine, 2026 Oct
PMID: 42885207
DOI: 10.1002/cam4.72357
10. Metabolic Dysfunction-Associated Steatotic Disease and Genetic Risk in Germany-An Observational Real-World Cohort Study.
Authors: Krawczyk M, Grünhage F, Schubert L, et al.
Journal: United European gastroenterology journal, 2026 Oct
PMID: 42841367
DOI: 10.1002/ueg2.70298
Authors: Park S, Gupta DK, Izzy M, et al.
Journal: Circulation, 2026 Oct 13
PMID: 42862908
DOI: 10.1161/CIRCULATIONAHA.126.079443
2. Review Article: Immune Effector Cell-Mediated Enterocolitis Following CAR-T Cell Therapy-Clinical Features, Pathophysiology and Management.
Authors: Damianos JA, Lin Y, Chen ZE, et al.
Journal: Alimentary pharmacology & therapeutics, 2026 Oct
PMID: 42596026
DOI: 10.1111/apt.70920
3. Systematic Review and Meta-Analysis: Plant-Based Therapy for Irritable Bowel Syndrome.
Authors: Meyer A, Auer J, Cascant-Ortolano L, et al.
Journal: Phytotherapy research : PTR, 2026 Oct
PMID: 42572206
DOI: 10.1002/ptr.70421
4. Targeting the CD31 immunometabolic axis: Precision strategies for modulating T cell activation, migration, and autophagy.
Authors: Han X, Yang F, Huang C, et al.
Journal: Pathology, research and practice, 2026 Oct
PMID: 42492206
DOI: 10.1016/j.prp.2026.156629
5. Gastrointestinal adverse effects of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists: A narrative expert review of approved therapies, oral formulations, and pipeline agents.
Authors: Singhani V, Ehsan M, Valencia S, et al.
Journal: Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2026 Oct
PMID: 42808923
DOI: 10.1002/ncp.70180
6. Impact of body composition on clinical outcomes in patients with hepatocellular carcinoma: A systematic review and meta-analysis.
Authors: Pinto E, Barberio B, Gambato M, et al.
Journal: Hepatology communications, 2026 Nov 1
PMID: 42878582
DOI: 10.1097/HC9.0000000000001063
7. Impact of immune checkpoint inhibitors as neoadjuvant/perioperative therapy for locally advanced resectable gastric/gastroesophageal junction adenocarcinoma: a systematic review and meta-analysis.
Authors: Chen Z, Liu X, Sun H, et al.
Journal: Frontiers in immunology, 2026
PMID: 42857192
DOI: 10.3389/fimmu.2026.1909466
8. Effect of a Phenotype-Tailored Lifestyle Intervention on Caloric Intake and Macronutrient Composition in Adults with Obesity: A Secondary Analysis of the PHENO-Diet Trial.
Authors: Espinosa MA, Sefried L, Villamarin J, et al.
Journal: Nutrients, 2026 Sep 25
PMID: 42884609
DOI: 10.3390/nu18193159
9. Safety Profiles of Immune Checkpoint Inhibitor Strategies in Gastrointestinal Cancers and Their Association With Clinical Outcomes: A Systematic Review and Meta-Analysis.
Authors: Lei J, Yu Y, Liu Q, et al.
Journal: Cancer medicine, 2026 Oct
PMID: 42885207
DOI: 10.1002/cam4.72357
10. Metabolic Dysfunction-Associated Steatotic Disease and Genetic Risk in Germany-An Observational Real-World Cohort Study.
Authors: Krawczyk M, Grünhage F, Schubert L, et al.
Journal: United European gastroenterology journal, 2026 Oct
PMID: 42841367
DOI: 10.1002/ueg2.70298
