Advancements in Gastroenterology: A Weekly Review
Gastroenterologia
Breakthroughs in Oncology and Gastroenterology
This week we discuss groundbreaking studies in oncology and gastroenterology, including new treatments for EGFR-mutated NSCLC, microbiome-based cancer therapies, H. pylori rescue regimens, and AI-assisted endoscopy findings.
Bibliography
1. Osimertinib plus datopotamab deruxtecan in patients with EGFR-mutated advanced NSCLC after progression on first-line osimertinib: ORCHARD.
Authors: Riess JW, Yu HA, Le X, et al.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology, 2026 Jun
PMID: 41780641
DOI: 10.1016/j.annonc.2026.02.014
2. Harnessing the microbiome for cancer therapy.
Authors: Hajjar R, Mars RAT, Kashyap PC
Journal: Nature reviews. Microbiology, 2026 Jun
PMID: 41486395
DOI: 10.1038/s41579-025-01268-6
3. Integrating PIK3CA Testing into Clinical Practice for Advanced HR+/HER2- Breast Cancer: An Expert Consensus.
Authors: De Angelis C, de Biase D, Gerratana L, et al.
Journal: Breast (Edinburgh, Scotland), 2026 Jun
PMID: 41999684
DOI: 10.1016/j.breast.2026.104786
4. Vonoprazan-Tetracycline Dual Regimen as Rescue Therapy for Helicobacter pylori Infection: Randomized Controlled Trial.
Authors: Gao W, Li J, Yang G, et al.
Journal: Gastroenterology, 2026 Jun
PMID: 41620038
DOI: 10.1053/j.gastro.2026.01.008
5. Anbenitamab in previously treated HER2-positive gastric cancer (KC-WISE): prespecified interim analysis of a randomized, phase III clinical trial.
Authors: Liu R, Zhao J, Zhang R, et al.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology, 2026 Jun
PMID: 41571045
DOI: 10.1016/j.annonc.2026.01.006
6. Psychomotor Development in Infants Following Maternal Exposure to Biologics: Results From the DUMBO Registry.
Authors: Palomino L, Velasco Rodríguez-Belvís M, Casanova MJ, et al.
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2026 Jun
PMID: 40518059
DOI: 10.1016/j.cgh.2025.05.012
7. Neoadjuvant Pembrolizumab in Stages I-III Deficient Mismatch Repair Colon Cancer: A Clinical Trial.
Authors: Gögenur I, Justesen TF, Tarpgaard LS, et al.
Journal: Annals of surgery, 2026 Jun 1
PMID: 39692004
DOI: 10.1097/SLA.0000000000006611
8. Tenofovir and Hepatitis B Virus Transmission During Pregnancy: A Randomized Clinical Trial.
Authors: Pan CQ, Dai E, Mo Z, et al.
Journal: JAMA, 2025 Feb 4
PMID: 39540799
DOI: 10.1001/jama.2024.22952
9. Building a Robust Investigator-Initiated Platform: The I-CARE Experience.
Authors: Kirchgesner J, Beaugerie L, Baumann C, et al.
Journal: Clinical pharmacology and therapeutics, 2026 Jun
PMID: 41693257
DOI: 10.1002/cpt.70231
10. Effect of a Computer-Aided Device for Detecting Gastric Neoplasms: A Multicenter, Randomized Controlled Trial.
Authors: Dong Z, Wu L, Du H, et al.
Journal: Gastroenterology, 2026 Jun
PMID: 41801173
DOI: 10.1053/j.gastro.2025.12.020
Authors: Riess JW, Yu HA, Le X, et al.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology, 2026 Jun
PMID: 41780641
DOI: 10.1016/j.annonc.2026.02.014
2. Harnessing the microbiome for cancer therapy.
Authors: Hajjar R, Mars RAT, Kashyap PC
Journal: Nature reviews. Microbiology, 2026 Jun
PMID: 41486395
DOI: 10.1038/s41579-025-01268-6
3. Integrating PIK3CA Testing into Clinical Practice for Advanced HR+/HER2- Breast Cancer: An Expert Consensus.
Authors: De Angelis C, de Biase D, Gerratana L, et al.
Journal: Breast (Edinburgh, Scotland), 2026 Jun
PMID: 41999684
DOI: 10.1016/j.breast.2026.104786
4. Vonoprazan-Tetracycline Dual Regimen as Rescue Therapy for Helicobacter pylori Infection: Randomized Controlled Trial.
Authors: Gao W, Li J, Yang G, et al.
Journal: Gastroenterology, 2026 Jun
PMID: 41620038
DOI: 10.1053/j.gastro.2026.01.008
5. Anbenitamab in previously treated HER2-positive gastric cancer (KC-WISE): prespecified interim analysis of a randomized, phase III clinical trial.
Authors: Liu R, Zhao J, Zhang R, et al.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology, 2026 Jun
PMID: 41571045
DOI: 10.1016/j.annonc.2026.01.006
6. Psychomotor Development in Infants Following Maternal Exposure to Biologics: Results From the DUMBO Registry.
Authors: Palomino L, Velasco Rodríguez-Belvís M, Casanova MJ, et al.
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2026 Jun
PMID: 40518059
DOI: 10.1016/j.cgh.2025.05.012
7. Neoadjuvant Pembrolizumab in Stages I-III Deficient Mismatch Repair Colon Cancer: A Clinical Trial.
Authors: Gögenur I, Justesen TF, Tarpgaard LS, et al.
Journal: Annals of surgery, 2026 Jun 1
PMID: 39692004
DOI: 10.1097/SLA.0000000000006611
8. Tenofovir and Hepatitis B Virus Transmission During Pregnancy: A Randomized Clinical Trial.
Authors: Pan CQ, Dai E, Mo Z, et al.
Journal: JAMA, 2025 Feb 4
PMID: 39540799
DOI: 10.1001/jama.2024.22952
9. Building a Robust Investigator-Initiated Platform: The I-CARE Experience.
Authors: Kirchgesner J, Beaugerie L, Baumann C, et al.
Journal: Clinical pharmacology and therapeutics, 2026 Jun
PMID: 41693257
DOI: 10.1002/cpt.70231
10. Effect of a Computer-Aided Device for Detecting Gastric Neoplasms: A Multicenter, Randomized Controlled Trial.
Authors: Dong Z, Wu L, Du H, et al.
Journal: Gastroenterology, 2026 Jun
PMID: 41801173
DOI: 10.1053/j.gastro.2025.12.020
